Cellular and molecular mechanisms of muscle atrophy
نویسندگان
چکیده
منابع مشابه
Cellular and molecular mechanisms of muscle atrophy
Skeletal muscle is a plastic organ that is maintained by multiple pathways regulating cell and protein turnover. During muscle atrophy, proteolytic systems are activated, and contractile proteins and organelles are removed, resulting in the shrinkage of muscle fibers. Excessive loss of muscle mass is associated with poor prognosis in several diseases, including myopathies and muscular dystrophi...
متن کاملMolecular and cellular mechanisms of skeletal muscle atrophy: an update
Skeletal muscle atrophy is defined as a decrease in muscle mass and it occurs when protein degradation exceeds protein synthesis. Potential triggers of muscle wasting are long-term immobilization, malnutrition, severe burns, aging as well as various serious and often chronic diseases, such as chronic heart failure, obstructive lung disease, renal failure, AIDS, sepsis, immune disorders, cancer,...
متن کاملMolecular Mechanisms of Muscle Atrophy
Skeletal muscle atrophy has extreme adverse consequences. Molecular mechanisms that mediate the process of atrophy are not well defined. Recent studies have focused on diverse molecular cascades that control the activation of ubiquitin ligases, indicating that the involvement of the ubiquitin proteasome may be common to a range of atrophic stimuli.
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متن کاملMolecular mechanisms of skeletal muscle atrophy
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ژورنال
عنوان ژورنال: Disease Models & Mechanisms
سال: 2013
ISSN: 1754-8411,1754-8403
DOI: 10.1242/dmm.010389